Workshop window: 12:30 – 13:15

Workshop window: 12:30 – 13:15

Chairs: to be defined
Sponsored by CCT-RNA
Mariana Mello, Scripps
Jamile Ramos da Silva, Hospital Israelita Albert Einstein
Santuza Maria Ribeiro Teixeira, UFMG

Sponsored by IMASP
Chairs: Roberto Giugliani & Antonio Carlos Campos de Carvalho, HCPA / UFRJ
Jim Wilson, Gemma Therapeutics
Milena Botelho Pereira Soares, Fiocruz-BA
Iscia Lopes-Cendes, UNICAMP

Chairs: to be defined
Veronica Lopez, Fundación Instituto Leloir
Marcio Chaim Bajgelman, CNPEM
Oral Abstract 80: NEUROGENIN 2 overexpression in corticospinal neurons modulates early neuronal and microglial responses after spinal cord injury
Oral Abstract 153: AAV-mediated overexpression of cannabinoid CB1 receptors preserves functional responses in a mouse model of retinitis pigmentosa

Chairs: to be defined
Stevens Rehen, Instituto D'Or
Patricia Braga, USP
Oral Abstract 37: Bioengineering a human lung-on-a-chip platform toward immune-informed preclinical modeling of pulmonary advanced therapies
Oral Abstract 66: Development and validation of a CAPN1 knockout SH-SY5Y cell model via CRISPR-Cas9 for SPG76 studies

Chairs: to be defined
Diego Villa Clé, USP-RP
Marina Carolina de Oliveira Rodrigues, USP-RP
Lorena Lôbo de Figueiredo Pontes, USP-RP

Chairs: to be defined
Marlon Lemos Dias, UFRJ
Silvya Stuchi Maria-Engler, USP
Oral Abstract 19: Experimental evolution of Zika virus for adaptation in differentiated cells of glioblastoma to enhance oncolytic activity
Oral Abstract 24: Air-jet-generated alginate microgels enable controlled and functional release of AAV vectors for gene therapy applications

Chairs: to be defined
Angela Saito — CNPEM
Davi Coe Torres — Hospital Israelita Albert Einstein
Oral Abstract 107: Sustained reactivation of fetal hemoglobin by adenine base editors in human hematopoietic stem cells for sickle cell disease
Oral Abstract 28: Gene therapy with AAV9 in cellular models for glutaric acidemia type I developed via CRISPR/Cas9 gene editing

Chairs: to be defined
Lucia Silla — HCPA-UFRGS
Mariana Marques — Hospital Albert Einstein
Oral Abstract 88: Lentiviral vector platform based on packaging cell line engineering and GMP-oriented process development
Oral Abstract 76: Establishing GMP-compliant CAR-T cell manufacturing at INCA for an upcoming pediatric clinical trial in Brazil

Chairs: to be defined
Leonardo Martins — University of Antwerp
Ana Paula Dinis Ano Bom — Bio-Manguinhos
Oral Abstract 170: Optimization and preclinical validation of an mRNA-LNP vaccine candidate against Chikungunya virus
Oral Abstract 57: Scaling up the non-viral production of CD19 CAR-T cells using a minicircle-based Sleeping Beauty transposon system

Chairs: to be defined
Lara Cristina Pereira — ANVISA
Luciana Piano — ARO-Einstein — Nova Regulamentação em Pesquisa Clínica
Mônica Felts — Diretora Científica, CNPq

Workshop window: 12:45 – 13:30

Workshop window: 12:45 – 13:30

Chairs: to be defined
Sponsored by INTERGEN
Juan Fueyo — MD Anderson Cancer Center
Candelaria Gomez-Manzano — MD Anderson Cancer Center
Wagner José Fávaro — UNICAMP

Chairs: to be defined
Sponsored by CCTA-EMBRAPII
Lucia Nassif Kerbauy — Hospital Israelita Albert Einstein
Augusto Barbosa Junior — Hospital Israelita Albert Einstein
Eduardo Ferreira de Carvalho Netto — Hospital Israelita Albert Einstein

Chairs: to be defined
Thiago Aparecido Silva - UNESP-Araraquara
Rodrigo Nalio Ramos  - Instituto D'Or
Oral Abstract 14: A Lentiviral EDV Platform for simultaneous CAR Engineering and CRISPR Gene Editing in Primary T and NK Cells
Oral Abstract 79: Cell therapy targeting fungal pathogens: optimization of Mannan-Specific Chimeric Antigen Receptor (M-CAR)

Chairs: to be defined
Ricardo Titze - UnB
Tatiana Martins Tilli - Fiocruz
Oral Abstract 42: Isoform-resolved lncRNA remodeling as a secondary readout of SCN2A dosage and CRISPRa-mediated activation in human iPSC-derived cortical excitatory neurons
Oral Abstract 34: From cells to patients: gene therapy with p14ARF and interferon-? reveals antitumor and immunomodulatory mechanisms in canine neoplasms

Chairs: to be defined
Fernanda Ferreira Cruz, UFRJ
Bruno Solano de Freitas Souza, Instituto D'Or
Oral Abstract 59: Investigation of the neuroprotective role of extracellular vesicles from physical exercise and associated with FNDC5/irisin in preclinical models of Alzheimer's disease
Oral Abstract 104: 3D Bioprinted Wound Dressings Containing 5-Azacytidine-Preconditioned Human Umbilical Cord Mesenchymal Stromal Cells for the Treatment of Severe Cutaneous Wounds in a Murine Model of Sickle Cell Disease

Chairs: to be defined
Hilda Petrs-Silva, UFRJ
Guilherme Baldo, UFRGS
Oral Abstract 17: Construction and evaluation of an HSV-1-based oncolytic virus expressing the pro-apoptotic protein sFTRAIL, for the treatment of head and neck tumors
Oral Abstract 146: Therapeutic DNA vaccination targeting HPV16 E5 and E7 oncoproteins: evaluation of different immunization regimens in a preclinical tumor model

Workshop window: 12:00 – 12:45

Workshop window: 12:00 – 12:45

Chairs: to be defined
Stephan Kadauke, CHOP
Juliana Dias, University College London
Oral Abstract 142: Phage display selection of scFvs specific for the HER2 S310F mutation from rationally designed libraries based on pertuzumab
Oral Abstract 6: Engineering CAR-T cells to enhance tumor infiltration in solid tumors

Chairs: to be defined
Juliana Maria Ferraz Salum, Escola Paulista de Medicina / UNIFESP
Jonas Alex Morales, UFRGS
Oral Abstract 187: Will It Reach Patients? An AI model predicts clinical translation of gene therapies from modifiable preclinical design choices
Oral Abstract 198: Safety and Preliminary Efficacy of a Brazil-Developed CMV pp65-Specific T-Cell Therapy for Clinically Significant CMV Infection After Allogeneic Hematopoietic Stem Cell Transplantation: Interim Results of a Phase I Study

Chairs: to be defined
Sponsored by ONCOTTGEN
André Silva Pimentel, PUCRS
Alfeu Zanotto-Filho, UFSC
Pedro Pires Goulart Guimarães, UFMG

Chairs: to be defined
Sponsored by INCT-Model3D
Marcelo Lazzaron Lamers, UFRGS
Fabio Papes, UNICAMP
Vanessa Morais Freitas, USP